STUDY OF PALM OIL AND GLUTAMINE AS FUNCTIONAL FOODS ON PEPTIDE TYROSINE TYROSINE (PYY) AND GLUCAGON-LIKE PEPTIDE 1 (GLP-1) IN OBESE PATIENTS FOLLOWING UP ON THE AMBULATORY HEALTH SERVICES OF THE PUBLIC HOSPITAL

Luciana Arantes Soares, ALEX AUGUSTO DA SILVA, ALESSANDRA BAZAGA BAPTISTA, THARSUS DIAS TAKEUTI, JUVERSON ALVES TERRA-JÚNIOR, Eduardo Crema

Resumo


Incretin-based therapies are an alternative for the treatment of type 2 diabetes and weight reduction.
In this respect, functional foods such as palm oil and glutamine are dietary strategies for the stimulation of intestinal peptides.
The aim of this study was to evaluate whether the palm oil capsules of ileal release (LI) and of glutamine (LI) result in increased
secretion of glucagon-like peptide-1 (GLP-1) and Peptide tyrosine tyrosine  (PYY).
Nineteen obese patients follow-up of the Ambulatory Health Services, received nutritional guidance and supplementation with ileal release capsules
containing palm oil and glutamine. Prospective analysis showed an increase in median GLP-1 levels between T0 (before treatment) and
T2 (after 2 months of treatment) from 21.9 pmol/liter (2-93) to 25.7 pmol/liter (3-92.5) (p= 0.564).
The baseline of peptide YY increased between T0 68.5 pg / mL (46.5 to 150) to 71 pg / mL (46-181) in T2 (p= 0.909).
Significant results with p <0.05 were considered.  Weight maintenance was observed during this period.  
Despite an increase in intestinal peptides in obese patients, no consistent increase in GLP-1 and PYY was observed.  

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